Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome

Hypoxia Inducible Factor1-alpha Genetic Polymorphism of Obstructive Sleep Apnea

Obstructive sleep apnea syndrome (OSAS) is characterized with recurrent collapse of upper airway during sleep and results in chronic intermittent hypoxia, which leads to activations of transcriptional factors and critical signaling pathways. HIF-1 is a central component of transcriptional factors involved in hypoxia-induced transcription of specific genes. Our oligo-microarray study showed both...

Sleep apnea and hypertension.

Sleep Apnea in Patients with Stroke and Related Risk Factors

  Background and Objectives: Sleep apnea involves repetitive cycles of obstructive sleep that disrupt sleep. This complication is the most important modifiable risk factors for stroke. The aim of this study was to assess sleep apnea in patients with stroke.    Material and Methods: In this cross-sectional study, 132 patients with stroke were recruited using convenience samplin...

Factors related to sleep apnea syndrome in sleep clinic patients.

We examined 129 patients recruited from two sleep clinics to study the sleep apnea syndrome (SAS), defined by the apnea-hypopnea index (AHI) > or = 10. Information was registered from a self-administered questionnaire, basal physical measurements, and polysomnography. In 68 subjects recorded for two consecutive nights, a high correlation was found between first- and second-night AHIs (r = 0.89)...

Obstructive sleep apnea and hypertension.

There has long been a recognized link between obstructive sleep apnea (OSA) and the cardiovascular system, no aspect of which has been more studied than blood pressure. Research in OSA has not only demonstrated dysregulation of homeostatic cardiovascular mechanisms but also has furthered our understanding of blood pressure regulatory control. Acute nocturnal blood pressure elevations associated...